It is critically involved in the self-renewal of undifferentiated embryonic stem cells. Our study demonstrates that OCT4 is a highly specific and sensitive immunohistochemical marker for primary intracranial germinomas.
Additionally, 49 primary and metastatic brain tumors that may be potentially confused with germinoma, either clinically or histologically, were investigated for OCT4 expression. “Role of Oct4 in the Early Embryo Development.” Cell Regeneration, vol. Introduction 4. PLAP immunoreactivity was detected in 23 of 25 cases and was absent in the remaining 2 cases.
[Google Scholar] 177. ehattab@iupui.edu Also known as OCT3, OTF3, and POU5F1, OCT4 is involved in the initiation, maintenance, and differentiation of pluripotent and germline cells during normal development. doi: 10.1097/00000478-200407000-00014. COVID-19 is an emerging, rapidly evolving situation. The follow-up durations ranged from 1 to 229 months (mean, 49 months; median, 23 months). Unable to load your delegates due to an error doi: 10.1038/modpathol.3800310.Pathology. OCT4 has been detected in primary testicular germ cell tumors with pluripotent potential: seminoma and embryonal carcinoma. Malignant mixed Mullerian tumor (MMMT) is an uncommon aggressive neoplasm composed of both malignant epithelial and mesenchymal components.
Pantazis G, Harter PN, Capper D, Kohlhof P, Mittelbronn M, Schittenhelm J.Pathology. 2015 May 1;8(5):5650-7. eCollection 2015. The other germ cell tumor components (yolk sac tumor, mature teratoma, immature teratoma, and choriocarcinoma) showed no staining. Each tumor was examined with hematoxylin and eosin staining and with antibodies to OCT4. Epub 2019 Apr 10.Liu B, Arakawa Y, Yokogawa R, Tokunaga S, Terada Y, Murata D, Matsui Y, Fujimoto KI, Fukui N, Tanji M, Mineharu Y, Minamiguchi S, Miyamoto S.PLoS One. 2020 Jul;44(7):e66-e79. Wolters Kluwer 2009 Sep;33(9):1293-8. doi: 10.1097/PAS.0b013e3181a3166d.Cao D, Allan RW, Cheng L, Peng Y, Guo CC, Dahiya N, Akhi S, Li J.Hum Pathol. doi: 10.1097/01.pas.0000149709.19958.a7.
The POU family is a homeodomain subgroup characterized by the presence of a ∼60 amino acid homeodomain (POU H) joined by a flexible linker to a second, independently folded ∼80 amino acid DNA-binding domain termed the POU-specific (POU S) domain (Herr et al., 1988).The two domains make separate contacts with the DNA (Klemm et al., 1994), as illustrated (left) for Oct1 (pink) … 321–329., doi:10.1038/sj.cr.7290134.Wu, Guangming, and Hans R Schöler. doi: 10.1097/01.pas.0000149709.19958.a7. It is expressed in mouse and human embryonic stem and germ cells but absent from all differentiated somatic cell types in vitro and in vivo. 2018 Sep 1;11(9):4622-4629. eCollection 2018.Gui H, Kolster RA, Palmer MB, Brooks JS, Zhang M, Husson MA.Curr Oncol.
Choriocarcinoma is the rarest of the germ cell tumors and is an uncommon component of … 28 (7): 935 – 940. Please enable it to take advantage of the complete set of features! In 2000, Niwa et al. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Immunostains, routine stains and molecular markers at PathologyOutlines.com Unable to load your collection due to an error
COVID-19 is an emerging, rapidly evolving situation. Germ cell neoplasia in situ, abbreviated GCNIS, is a premalignant lesion of the testis.. 121,3 (2005): 465-77. doi:10.1016/j.cell.2005.02.018Heurtier, V., Owens, N., Gonzalez, I. et al. In addition, we examined sections from spermatocytic seminomas (5), Leydig cell tumors (8), Sertoli cell tumors (6), unclassified sex-cord stromal tumors (4), adenomatoid tumors (2), testicular tumor of adrenogenital syndrome (1), and granulosa cell tumor (1). OCT4 is an 18-kDa POU-domain transcription factor encoded by the POU5F1 gene. Hattab EM(1), Tu PH, Wilson JD, Cheng L. Author information: (1)Department of Pathology and Laboratory Medicine, Indiana University Medical Center, Indianapolis, IN 46202, USA.
Nat Commun 10, 1109 (2019). [Google Scholar] 38. Syncytiotrophoblast cells, which were present in 15 of the cases, were also completely negative, as were all 5 of the spermatocytic seminomas. 2019 Sep 11;10:619. doi: 10.3389/fendo.2019.00619. OCT4, CD30 and GPC3 are useful in confirming the diagnosis; OCT4 and CD30 are positive while GPC3 is usually negative in embryonal carcinoma, and the staining pattern is reversed in yolk sac tumor. This site needs JavaScript to work properly. eCollection 2019.Stem Cell Rev Rep. 2018 Oct;14(5):715-721. doi: 10.1007/s12015-018-9832-y.Gainetdinov IV, Skvortsova YV, Kondratieva SA, Klimov A, Tryakin AA, Azhikina TL.BMC Cancer.
They develop on areas of skin that often flex — such as the lower abdomen, upper thighs or armpits. “Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.” Cell vol. It was previously known previously known as intratubular germ cell neoplasia (abbreviated ITGCN) and testicular intraepithelial neoplasia. doi: 10.3747/co.26.5179. Epithelial mucin expressed in intestinal goblet cells and airway epithelium; gene is at 11p15.5 Relatively specific for predicting colorectal origin for Paget disease (Am J Surg Pathol 2001;25:1469) Gel forming MUC2 mucin may act as barrier to prevent infiltration of malignant cells in breast mucinous / colloid carcinoma We do not ask for personal information or make personal information available to advertisers. Epub 2019 Oct 1.Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Goltsov AY, Solovyev V, Brizgalov L, Filippova E, Weng Z, Akbarian S, Rogaev EI.FASEB J. 3, no. We examined histologic sections from 91 primary testicular neoplasms, including 64 cases of mixed germ cell tumors containing embryonal carcinoma (54), seminoma (51), yolk sac tumor (38), mature teratoma (31), immature teratoma (20), and choriocarcinoma (15). 2006;13(2): 76 – 79. Immunohistochemistry results demonstrated that SOX2 was expressed in all cases of gliomatosis peritonei and glioma with tissue available (9 of 9 cases), whereas OCT4 and NANOG were negative in all cases with available tissue (8 of 8 cases). doi: 10.3747/co.26.5179. Please enable it to take advantage of the complete set of features!
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